The highly polymorphic swine leukocyte antigen (SLA) genes have been repeatedly shown to influence swine immune traits, disease resistance, vaccine responsiveness and tumour penetrance.
SNPs on the APOA1/ C3/ A5 gene cluster, which is involved in lipid metabolism, are highly associated with dyslipidemia, metabolic syndrome, insulin resistance and responsiveness to relative treatments [ 19].
The observed corticosteroid epithelial relative resistance, but responsiveness toward inhibition of IKK2 in donors with and without asthma, would suggest that corticosteroid epithelial unresponsiveness is related to features of the canonical NF-κB signaling pathway.
CNPs of gene(s) related to disease resistance or susceptibility, responsiveness to a particular drug, and aging ailments have been reported [34].
Beeram et al. [48] found that cotreatment with the mammalian target of rapamycin (mTOR) inhibitor RAD-001 reverses the AKT-mediated resistance and restores responsiveness to antiestrogens.
Resistance and low responsiveness to antiangiogenic tyrosine kinase inhibitors such as sunitinib is a major clinical obstacle in the treatment of mRCC.
The target traits have also been broad, ranging from enhanced dessication tolerance and nematicide resistance, to increased responsiveness to herbivore-induced plant signals.
Although this selective deterioration of type II fibers and their SC content in human skeletal muscle is partly reversible by resistance training, the responsiveness of SCs to a single bout of resistance exercise is reduced with aging.
At 8 weeks of age (7 weeks PI), arsenic-exposed mice had increased airway resistance, increased airway responsiveness to MCh, and increased airway smooth muscle mass compared with control mice.
This trial is uniquely stratified for obesity and should help answer the question of whether obesity and insulin resistance will predict responsiveness to metformin for cancer treatment, as some of the preclinical studies suggest 20, 38, 39.
