Exact(1)
Finally, cumulative virological response and HBV resistance probabilities of ETV and TDF were assumed to be similar for both cohorts.
Similar(59)
Key research areas that need to be addressed concern associated morbidity (anorectal and reproductive morbidity due to extra-genital infections), 'the best' management strategies, including testing and treatment for extra-genital CT, extra-genital treatment resistance, transmission probabilities between partners and between anatomic sites in a woman, and impact on transmission of other infections.
On the basis of genetic point mutation as a source for the resistance, the probability formula for existence of resistant cells at a tumor size was constructed.
However, for high treatment levels and low to moderate costs of resistance, this probability remains above 0.5, implying that clinical immunity has not increased enough to tip the balance in favor of the wild-type by creating a refuge, an that the majority of the solutions have not crossed the threshold.
The complex relationships between host-adaptation, carriage of antimicrobial resistance and probability of cure among S. aureus strains warrants continued study [ 16].
10, 11 The choice of the antiretroviral regimen is highly individualized and based on considerations such as primary resistance, the probability of treatment interruptions or nonadherence, drug interactions with HIV and concomitant medication, as well as on patient desires.
So, if inactivation of a gene is an important mechanism driving the acquisition of drug resistance, the probability of this occurring by methylation and being selected for during chemotherapy is much more likely than it occurring by mutation.
This will decrease the probability of resistance and increase the probability of partnering and collective strategic thinking.
Hence, a mixture of reconstructed mutagenetic trees represents possible evolutionary pathways towards drug resistance along with probabilities for the development of the involved mutations [14].
While we do not explictly model these differences, we note that the mechanisms of resistance and their probabilities affect the relative importance of de novo resistance compared to pre-existing resistance circulating in a population (Lipsitch and Samore, 2002).
In this stage of the infection, we calculate the probability (Pb) that resistance emerges and the probability that resistant gametocytes are produced and sampled by a mosquito during a blood meal.
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