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The central resistance model states that central hypothalamic pathways are defective (resistant to leptin and others such as insulin).
Using various in vitro and in vivo assays, we tested the effect of roscovitine on three hormonal therapy-resistant model cells: (a) MCF-7-TamR (acquired tamoxifen resistance model); (b) MCF-7-LTLTca (acquired letrozole resistance model); and (c) MCF-7-HER2 that exhibit tamoxifen resistance (ER-growth factor signaling cross talk model).
A simple diffusion resistance model was then proposed and validated by experiments.
The core part is simulated by a distributed resistance model.
Douthat, himself a conservative Catholic, believes that evangelicals generally hewed to the resistance model.
Other groups, including the I.R.A., Al Qaeda and right-wing patriot factions, were organized around this leaderless resistance model but never were truly leaderless.
A simple diffusion resistance model is shown to be sufficient to capture the effects of both intracrystalline and surface diffusion resistances, thus properly linking simulation to experimental evidence.
Experimental results (symbols) are fitted by the diffusion resistance model (black line) in equation (4) (α=5.0 × 10−9 m s−1; coefficient of determination R2=0.94).
Using equation (1) in combination with the parallel resistance model (Methods and Supplementary Fig. 3), we simultaneously fit the resistance versus voltage cycles and the STDP curve.
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Next, a parallel permeation-resistance model of the skin barrier was established.
The potentiodynamic current potential behavior is adequately described by using the layer-pore-resistance model (LPRM).
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