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Hence, recent efforts to overcome antifolate resistance focus on the design of antifolates with enhanced selectivity toward PCFT.
A few of the more widely studied areas today in drug resistance focus on the contributions of cancer stem cells (CSCs), inducers of drug efflux pump expression and inhibitors of apoptosis [ 4].
Prevailing theories for insulin resistance focus on lipid-mediated mechanisms but also include insulin resistance mediated by elevated concentrations of amino acids and inflammatory signaling molecules as well as combinations of these (2).
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Previous metabolomics studies of insulin resistance focused largely on obese, insulin-resistant compared with lean, insulin-sensitive individuals (25, 28, 29).
Wartime work at a blood transfusion center for the Resistance focused him on building France's blood product industry.
Later, when his mother began to have doubts about her plan to write a book about the Italian resistance, focused on themes of social upheaval, it was Mr. de Blasio who made sure she finished it.
Advocates of such views tend to stress the distinctive role of imagination in imaginative resistance, focusing on ways that imagination may implicate the subject's actual beliefs and desires.
The tests have been focused on the main requirements of an industrial pavement: abrasion resistance, impact and chemical attack resistance focusing on the most common type of chemical aggression in industry.
This resistance focused on two things: the King's right to demand military service, and his right to levy taxes.
Much of the literature on antibiotic resistance focuses on tolerance to the high antibiotic levels typically used in a clinical setting (see [5] for an exception).
Expanded surveillance allows for molecular mapping and enables a rapid containment of resistance foci.
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