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Exact(4)
2. the root mean square deviation (RMSD) of the matched residues (points).
At present, there is a consensus among molecular biologists in the use of the following two parameters [ 2- 4]: 1. the number of residues (points) or percentage of total residues (points) matched in the alignment.
The presence of a large number of positively charged amino acid residues points to possible cytotoxic functions of these peptides.
Interestingly, several other positions in our phylogenetically broad multiple alignment are fairly well conserved across eukaryotes (and in some cases, bacteria), but not in Cam; it is possible that the conservation of these residues points to novel, potentially important functional sites.
Similar(56)
A report that was published during the licensing process said analysis of seabed samples had found residues pointing to the presence of oil, offering further encouragement.
Several of the residues pointed out herein have been recently associated to NRTI exposure or increase drug resistance to NRTI.
The residues involved in this positioning, i.e. those interacting with DNA, were matching the residues pointed out by former biochemical studies.
The side chains of this ATP-binding motif residues point toward the cleft between the N-lobe and the C-lobe.
The effects of G730W and V734Y mutations on the interaction suggest that these residues point towards the interface, as predicted in our model (Figure 3C).
The homologous residues of position 595 are generally represented by large, hydrophobic residues pointing to preservation of the hydropathy profile at this position, and suggesting a mechanistic role for those residues in kinase function (Figure 1A).
It is of note that in contrast to the majority of inward pointing side-chains identified by our study, several hot-spot residues point out towards the membrane (figure 3a).
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