The deflagration front chemistry of RDX is dominated by the intermolecular and the intramolecular H-transfer reactions and subsequent formation of short-lived heavier polyradicals similar to the non-volatile residue reported in the literature.
Finally, LiTXN3 has a Lys at position 112, instead of a Glu residue, reported to be involved in interaction of TXNs with nsGPXs [23], the second family of TXN-dependent peroxidases.
In the present study, when the target sequence was aligned with the template sequences during homology modeling procedure, it resulted in aligning the conserved Gly in H5 and hence in our models, the residue at H5 position of ar/R filters is the alternate residue reported in their paper [ 24].
This value is clearly much smaller than those calculated and measured for residues reporting on process III.
C′, Cα and methyl-C (CH3) CEST profiles for pWT residues reporting on transient local folding (C – E ).
(A, B ) N CEST profiles of residues reporting on transient local folding at two different concentrations of pWT apoSOD12SH (red: 1.3 mM, green: 0.7 mM).
When more than a single exchange event is present residues reporting on a specific process may be localized structurally (Vallurupalli and Kay, 2006), simplifying the analysis.
Moreover, relaxation dispersion data from residues reporting on processes III and IV are all well fit to a two-state model.
(B ) These dispersion profiles cannot be fit together with those from residues reporting on non-native oligomerization process III and the resulting Δϖ values are in error (C, blue).
Further, in A4V apoSOD12SH minor dips in N CEST profiles involving residues reporting on process II could be distinctly observed, though those for the concentration-dependent processes I, III, and IV were no longer present.
