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In addition to their ability to produce signature cytokines, ILCs are interesting in that they are primarily tissue resident lymphocytes.
However, skin resident lymphocytes can become activated in human skin explant assays [54].
Altogether, the striking reduction in resident lymphocytes in spleen, and lungs, and the increase in circulating leukemic cells in mice treated with CDDO-Im, suggest that this CDDO-derivative induces mobilization of tumor cells from lymphoid organs and infiltrated tissues into the circulation.
CDDO-Im treatment initially resulted in an increase of circulating B cells, which correlates with a reduction in resident lymphocytes in spleen, and lungs, suggesting that CDDO-Im induces mobilization of tumor cells from lymphoid organs and infiltrated tissues into the circulation.
Histochemical analysis of spleens of TRAF2DN/Bcl-2 mice with overt disease following treatment with CDDO-Im showed a dramatic reduction in resident lymphocytes in spleen, and the lungs of CDDO-Im-treated mice showed essentially no lymphocyte infiltration by the end of the treatment (Figure 6).
10% of total lung resident lymphocytes are NK cells.
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However, the consequence of obesity and metabolic disease on the function of skin resident lymphocyte populations and how this contributes to skin complications associated with obesity and metabolic disease are unknown.
The liver, like the skin and gut, is a major site of antigen presentation with its own resident lymphocyte population.
Sherlock et al 18 demonstrated an IL-23R+ entheseal resident lymphocyte cell population that is activated by IL-23, that produces IL-22, and can promote entheseal and periosteal bone formation.
Fan, X. & Rudensky, A. Y. Hallmarks of tissue-resident lymphocytes.
In future studies, it would also be worthwhile to comprehensively evaluate mucosal specimens, and tissue- or lymphatic tissue-resident lymphocytes.
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