That reshuffling effect impresses and reconciles critical theorists like Foster and aesthetes like me, who are apt to bristle at one another.
Such reshuffling effectively homogenizes the evolutionary rates of individual domains.
Regardless of their potential effects on reshuffling genes and/or chromosomal domains (e.g. amplification, deletion, inversion, etc).
Accumulating evidence for recombination among Chlamydiaceae in general, and C. trachomatis in particular, has motivated a typing system that provides buffering from the distorting effects of genetic reshuffling that plague systems based on a single locus.
While these latter processes can have the effect of homogenizing contemporary gene pools [ 5, 6], the reshuffling that occurs with each sexual generation also allows different loci to follow different genealogical histories and respond differently to the effects of mutation, drift, selection, and gene flow [ 7- 10].
To curb possible bias in the target prediction and isolate the effects of clustering, a control was generated by randomly reshuffling miRNAs (or families, when studying family-represented hetero-clusters) among the clusters.
By contrast, because the expression level differences (Dicer KO vs control) were untouched by the reshuffling of timepoints, a sizeable number of permutations still showed amplitude effects comparable to the original data.
To ensure that the effects observed were related to the parameter of interest, we designed a reshuffling scheme for each parameter.
In order to eliminate effects of kin competition, but retaining all other characteristics of local populations, we performed a reshuffling experiment.
Future comparative research on the effect of chromosomal reorganization on recombination as outlined above should be an effective means to enhance our knowledge of the role of genome reshuffling in evolution.
