Resetting activity of DNA repair genes can diminish deleterious effects of aging.
This implies that the SCN and OPN require a strong photic input to reset intrinsic activity.
This takes place in the local microcircuit by the i-specic projection from L2/3 to L4 interneurons, which can use the additional excitation to reduce (or reset) the activity of L4 excitatory cells.
Thus, BIns and other L4 interneurons generate a "brief window of excitability" during which spike generation in L4 spiny neurons can occur (Swadlow 2003) and can ultimately shut down excitation and "reset" spiking activity.
Further experiments confirmed that oxyntomodulin's liver resetting activity depends on it stimulating glucagon receptors (and not GLP-1 receptors).
The adaptation module gradually resets the activity and sensitivity of the first module after initial stimulation and thereby enables the temporal comparisons necessary for bacterial chemotaxis.
We screened a commercially available metabolic peptide library (Obesity Peptide Library, Phoenix Europe GmbH; DE) for factors capable of resetting luciferase activity rhythms in organotypic liver slice cultures from Per2::LUC circadian reporter mice (Yoo et al., 2004).
This mechanism may be relevant to cocaine abuse in the context of extracellular matrix remodeling, in that a cocaine induced reset of pacemaker activity might be an underlying activity dependent metaplasticity that functions as a trigger for the consolidation or adaptive generalization of memories of an intense euphoria.
Two mechanisms of stimulus-controlled transducer methylation seem possible: the stimulus-activated transducer molecule may be methylated/demethylated to reset its signaling activity to the pre-stimulus level, or other, i. e. non-stimulated transducers may be methylated/demethylated through a coupling mechanism or feedback loop to attenuate their constant signaling output.
Simulations illustrated that prolonged periods of decreased activity reset synaptic strengths to low values, suggesting a plausible forgetting mechanism.
A hormone released from the gut after a meal can reset clock gene activity in the liver.
