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World health authorities, concerned with cost and drug resistance, initially said antibiotics should be reserved for severe cases.
Drugs to prevent or treat osteoporosis include bisphosphonates like Merck's Fosamax, which permanently bind to bone; parathyroid hormone, which is generally reserved for severe osteoporosis; Eli Lilly's Evista, which acts like estrogen on bone but also can cause hot flashes and blood clots; and calcitonin, a less effective treatment that is administered as a nasal spray.
As no well-controlled data is available for his indication for now it should only be reserved for severe treatment-refractory chronic migraine patients [37, 61, 87].
Understanding the natural history and good response to corticosteroids of most ipilimumab ocular irAEs is important for management, as discontinuation of ipilimumab therapy is reserved for severe or life-threatening irAEs.
In North America, Shindo noted, treatment with antiviral drugs is largely reserved for severe cases and people who are at greater risk from the virus because of other underlying health problems or pregnancy.
Oral isotretinoin is usually reserved for severe acne due to greater potential side effects.
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"By ensuring that the most severe penalties are reserved for serious drug traffickers, we can reduce unfair disparities in our criminal justice system and reduce the burden on our overcrowded prison system.
16 Oral antibiotics may be used for less severe infections with intravenous (IV) antibiotics reserved for more severe infections such as advancing cellulitis or osteomyelitis.
For >2 decades, these guidelines have recommended classification into 4 classes of severity based on clinical signs at initial presentation, with inpatient management reserved for the severe categories [ 3].
Its author, Dr. Scott M. Kaszuba, speculated that antihistamines would be less effective if used as needed, even though antihistamines were more commonly prescribed, with steroids usually reserved for more severe reactions.
The savings from early intervention usually show up within a year, Dr. Humphreys said, and most patients with a new diagnosis would get consultations with nurses, doctors or therapists, rather than expensive prescriptions for medicines typically reserved for more severe abusers.
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