DrotAA = drotrecogin alfa activated; PROWESS = Recombinant Human Protein C Worldwide Evaluation in Severe Sepsis; RESOLVE = Researching Severe Sepsis and Organ Dysfunction in Children: A Global Perspective.
An FDA-mandated paediatric trial, RESOLVE (REsearching severe Sepsis and Organ dysfunction in children: a gLobal perspective), was therefore conducted.
The efficacy and safety of drotrecogin alfa activated (DrotAA) (recombinant human activated protein C) was assessed in children with severe sepsis in the Researching Severe Sepsis and Organ Dysfunction in Children: A Global Perspective RESOLVEE) study [ 1].
The Researching Severe Sepsis and Organ Dysfunction in Children: A Global Perspective study of drotrecogin alfa activated versus placebo was the largest study of adjunctive therapy ever performed in children with severe sepsis.
Safety and efficacy of DrotAA in paediatric patients with severe sepsis were to be evaluated (the REsearching severe Sepsis and Organ dysfunction in children: a gLobal perspectiVE [RESOLVE] trial [ 17]).
From a safety point of view, in the RESOLVE (REsearching severe Sepsis and Organ dysfunction in children: a gLobal perspective) study [ 24], a double-blind, placebo-controlled trial conducted in children with severe sepsis, the investigators attributed two deaths in the DrotAA group and five in the placebo group to bleeding events.
A separate trial, RESOLVE (REsearching severe Sepsis and Organ dysfunction in children: a gLobal perspectiVE), was initiated to investigate the efficacy and safety of DrotAA in children [ 16] but did not report any beneficial effect of DrotAA and was also stopped early.
This paper validates previous research indicating severe land degradation in the second half of the 20th century.
Moreover, the usefulness of PG measurements in the research of severe meteorological phenomena such as thunderstorms cannot not be disregarded (Pawar et al. 2014; Pawar et al. 2015).
The last 20 years of research on severe accident safety for light water reactors (LWRs) has resolved a number of issues.
Even if the industry and the World Health Organization claim that glyphosate is a product of low-toxicity, an increasing body of scientific research shows severe health problems for villagers and farmers.
