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Given that the results of this survey support previous research, in that the term 'impact' had different meanings for researchers across the cancer research continuum, it may be advisable that cancer funding bodies communicate their expectations early, at the grant acceptance stage, about the extent and types of data they expect grant recipients to collate.
A more complete integration of T3 translational research into the more traditional research continuum is necessary if we are to achieve the best possible outcomes for our patients.
Health improvements seen both for individuals and populations are fully dependent upon the quality of validation of new scientific discoveries within the CTM research continuum and strong evidence of benefits and risks associated with therapeutic interventions.
The identification of rapamycin from Streptomyces hygroscopicus as an antifungal agent, through being an immune inhibitor to being an effective anticancer drug, demonstrates a research continuum driven by clinical observations that were critical in the elucidation of the mTOR pathway.
This chapter reviews several notable clinical trial designs, emphasizing the importance of matching the specific design selected to both the purpose of the trial and where the specific question being addressed sits on the spectrum of the research continuum.
While the need for research as the T1 and T2 stages of the translational research continuum is not diminished, as noted by the IOM [1] clinical care within the healthcare system and the role of communities in reducing health disparities present clear 'next steps' in the efforts to reduce health disparities.
Similar(42)
Our analysis draws on two frameworks, Sumner et al's synthesis approach and Nutley's research use continuum.
These four case-studies were interrogated using Sumner et al's synthesis approach [ 1] and Nutley et al's research use continuum [ 4] to identify lessons and the dominant types of research use.
Three of the case studies highlighted that policies were not being implemented on the ground, highlighting the potential for undertaking a process of engagement with practitioners and creating mechanisms for follow-up as part of the research use continuum.
In line with our organization's conceptual ethics framework [ 21], the PHO Risk Screening Tool was developed to permit review of all evidence-based initiatives across the research-practice continuum.
The ability to consider context improves the specificity of risk assessment, which is valuable in any ethics oversight system, but which would be particularly important in supporting ethics oversight across the research-practice continuum.
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