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Synthetic shh mRNA injection rescued effects of ethanol exposure in zebrafish (Loucks and Ahlgren, 2009).
The rescuing effect was least effective in the larvae of the 5 dpf/2-hr group (ginkgotoxin and PLP/GABA were added at 5 dpf for 2 hours).
Whether the pore features are necessary for the function leading to the rescuing effect is presently unknown.
The strong rescuing effect of DIDS on curcumin-induced apoptosis as observed in this study, however, makes it hard to envision a channel without a role for VDAC.
What is the mechanism(s) underlying the rescuing effect of cold?
In contrast, knocking down Klf5 in Mbd3 −/− ESCs had no rescuing effect in this assay.
We did observe a BDNF rescuing effect on EphB3−/− OPCs following staurosporine treatment.
The rescuing effect of HDAC was again abolished in flies with impaired autophagy [ 223].
No rescuing effect could be detected by targeting either egl-15 or sur-7 in body wall muscles.
This rescuing effect of hypoxia could be mimicked by the addition of recombinant human VEGF to serum-deprived cells.
Overexpression of Smad1 alone had no promoting effect on axon growth, similar to what we observed before, further confirming the rescuing effect of Smad1.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com