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These rescue pathways must be supplied components in order to preserve the cell and maintain homeostasis.
For HCT116 all correlations are positive in hypoxia which suggests the response to low oxygen is to up-regulate rescue pathways.
Facing the challenge and delineating the neurodegenerative and neuron rescue pathways in NPC genetic animal models might provide leads that are relevant to the pathology of other neurodegenerative disorders.
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Finally, PCNA SUMOylation blocks a third, more dangerous rescue pathway (Pfander et al, 2005).
Under these conditions AMP-kinase activity acts as a rescue pathway.
Nrf2 activates a cellular rescue pathway that protects against the LPS-induced inflammatory response [ 47].
Nrf2 induces a cellular rescue pathway that protects against LPS-induced inflammatory stress [ 47].
In addition, all these works add to the growing consensus that autophagy plays an important role as a "normal" cellular degradation pathway, rather than representing solely a "rescue" pathway designed to supply critical nutrients during starvation.
The present study aimed at clarifying whether exposure of endothelial cells to pro-inflammatory HOCl HDL impacts on expression of heme oxygenase-1, a potential rescue pathway against endothelial dysfunction.
Hepatocyte growth factor signaling through the c-met receptor activates mitogen-activated protein kinases independently of Ras, and could represent a rescue pathway around Ras inactivation by ZA [ 60].
The therapeutic strategy, consisting in the combined treatment of AdNK4 plus DAS, inhibited in bone metastatic tissue both the HGF/Met signaling cascade and the total Src activity, hampering escape strategies of metastatic cells through Src-dependent rescue pathway(s).
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