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Other genetic interactions, such as 7,233 synthetic growth defect and synthetic rescue interactions were not included.
43, 44 Synthetic rescue interactions improve fitness at the expense of robustness.
Synthetic rescue interactions are not associated with co-conservation, which is to be expected because such interactions indicate a complementary rather than synergistic relationship.
We then compared our predictions to other sets of TF interactions discovered via high-throughput experiments: physical interactions, synthetic lethal interactions, and synthetic rescue interactions (Table 1).
I specially discuss how rescue interactions can lead to the rational design of antagonistic drug combinations that select against resistance and how they can illuminate medical research on cancer, antibiotics, and metabolic diseases.
Similar(55)
Other significant categories belong to functions of metabolism, cell rescue, interaction with the environment and subcellular localization (Fig. 1B).
Specifically, future rescued populations from the diversified treatment declined less rapidly than did those finally going extinct (significant treatment × rescue interaction: F1,50 = 4.61, P = 0.0366; Fig. 2B).
Many of the genes (up-regulated and down-regulated) fell into the Cell Rescue, Interaction with Cell Environment and Interaction with the Environment categories, which are generally associated with stress responses or hormone signalling.
In the absence of "rescuing" interactions, clustering of FX regions is certainly occurring (it is much easier than intermolecular interactions and those are readily observed as hydrogel formation).
Eukaryotic EF1 family members Hbs1 and eGTPBP have seemingly independently evolved roles in ribosome rescue via interactions with the eRF1 paralogue Dom34 [ 21, 55].
Furthermore, TSA together with TPA, but not in combination with nocodazole, was able to rescue this interaction.
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CEO of Professional Science Editing for Scientists @ prosciediting.com