In this immunopathogenesis paradigm the eradication of T. cruzi may be a pre-requisite to control the disease progression and prevent the irreversible long-term consequence of Chagas disease.
Whole-cell aspiration and the requisite need to control cell position within the micropipette required the precise manipulation of picoliter volumes of cell culture media.
Set in a sort of sporting prison camp players have to successfully complete a series of heading tests, using just the requisite body movement to control the ball into a variety of tests and targets.
These two issues are interrelated because a suboptimal dose of umbilical cord blood might provide neither the critical mass of Tregs to control autoimmunity nor the requisite number of stem cells to increase pancreatic β-cell mass.
Prior to control, it is important and necessary to find out the process deviation from the requisite normal operating region at an early phase to avoid the huge revenue loss.
If the authors can establish whether TSLP acts directly on inflammatory or other cell populations to control tumor formation, this would represent the kind of mechanistic advance requisite for eLife.
These parameter estimates are essential pre-requisites to the development of formal approaches for the quantitative evaluation of different strategies to control this neglected disease.
Key to controlling the waves inside a material is providing the requisite geometry (lattice, symmetries, topology, scale) as well as both the appropriate intrinsic component material parameters and the emergent properties expressed by the structural building blocks.
Since the advent of highly active antiretroviral therapy (now referred to as combination antiretroviral therapy [CART]), high levels of adherence are requisite to achieve maximal viral control and to improve immunologic status, which results in fewer acquired immunodeficiency syndrome defining events and lower mortality.
Interestingly, Mdh was the only recombinant protein of the five antigens examined which facilitated some level of clearance that elicited a significant IFN-γ response, a cytokine critical for the activation of macrophages and a requisite for controlling Brucella infections [30].
Understanding its spatial distribution is a requisite to evaluate the public health implications and to design disease control schemes.
