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Werner, J. L. et al. Requisite role for the Dectin-1 β-glucan receptor in pulmonary defense against Aspergillus fumigatus.
Pab1 binds mRNA as part of its normal function, and disrupting RNA binding or altering cytoplasmic mRNA levels suppressed the cytotoxicity of 17A-expanded Pab1, indicating a requisite role for mRNA in Pab1 polyA-expansion toxicity.
As previously reported for ischemia-reperfusion injury [26], we found that administration of rhBCL2A1 failed to protect TLR2-null mice from sepsis-induced mortality, indicating that there is a requisite role for TLR2 signaling for the protective effect in vivo.
Together, these findings argue against a requisite role for S1 cleavage in physiologic or pathophysiologic Notch receptor activation, and highlight how subtle differences among Notch receptors in response to S1 cleavage may result in receptor-specific functional consequences.
The inability of rhBCL2A1 to protect the TLR2−/− or MyD88−/− mice against I/R injury of skeletal muscle indicates a requisite role for TLR2-MyD88 signaling for cytoprotection in vivo.
Moreover, studies summarized above have demonstrated a requisite role for progesterone in the induction of mammary cancer development by E2 in ACI rats [ 13, 19].
Similar(53)
Still others represented reconstructive epistemological projects in response to such findings, arguing for a requisite role of values in scientific theorizing, or arguing that rational investigation requires a critical assessment of the metaphysical (and sometimes gendered) assumptions underlying a field of study.
The current results suggest that the discovery of the semantic (animate-inanimate) distinction and its requisite role in the AMR was crucial for accurate generalization to new items.
Sequential upregulation of these two proteins plays a requisite role in providing costimulatory signals required for efficient B-cell antibody production and isotype class switching [ 42, 43].
This indicates that Sch9 per se is not necessary for the glucose response, whereas PKA plays a requisite role.
On the other hand, S6K1 is known to play a requisite role in the regulation of autophagy in Drosophila [ 28], making it a promising candidate for the in vivo target of resveratrol that is responsible for inhibition of autophagy.
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