Since formation of at least a four-domain structure is a pre-requisite for the activity of half-molecule ABC transporters [13], [14], [16], [21], and truncated HMT-1 does not self-associate, we expected that truncated HMT-1 would not confer Cd tolerance in S. cerevisiae.
Adaptation to the colon environment is requisite for the active release of propionibacterial beneficial metabolites and constitutes a bottleneck for metabolic activity in vivo.
At least for the archetypal mutants, i.e. Δ5 and the pair Δ6 and Δ7, the ER export process was found to be a pre-requisite for the enzymatic activity, indicating possible differential functions for individual N-glycans in tyrosinase traffic.
Combined with our determination that the pharmacophore elements requisite for activity in the steroidal series are required for optimal antiproliferative activity in THIQs both with, and without, a substituent at C-3 these results serve to validate our design hypothesis.
Therefore, the establishment of atypical ectopic niches upon stem cell therapy, at either the level of the CNS or in peripheral immunologically relevant sites, might be realistically advised as the functional (pre) requisite for the long-term therapeutic activity of transplanted stem cells.
Presence of partially sulfided phase originated from rather segregated structure like Pd Pt/Al2O3 is thought to be requisite for high HDA activity.
This is requisite for the subsequent evaluation of the structural model [28, 30].
The predominant requisite for the targeted tumour antigen is cell surface expression.
This abnormality may be an important requisite for the development of spontaneous arthritis.
Docking of HAC1 mRNA at the -box is a pre-requisite for Ire1 activity in vivo, in agreement with our previous finding that the -box-containing linker enhances the RNase activity of Ire1 by more than 100-fold in vitro (Korennykh et al., 2009).
