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The existence of a TXN within the mitochondrion of trypanosomatids, capable of driving crucial redox pathways, is considered a requisite for normal parasite metabolism.
As the maturation of APP and the cleaving secretases requires trafficking through the secretory pathway [9], [10], [11], we hypothesized that ER stress may block trafficking requisite for normal levels of APP cleavage and that the small molecular chaperone 4-phenylbutyrate (PBA) may rescue the proteolytic deficit.
These events require the expression/overexpression and activation of molecules not generally requisite for normal cellular functions.
A delicate regulation of this process is requisite for normal bone homeostasis, and an imbalance is often related to metabolic bone diseases in humans [ 2].
Intraluminal EVTs occlude uterine spiral arterioles to maintain a low oxygen tension environment that is requisite for normal early placental and fetal development.
A study with Rspo2 gene-targeted mutant mice observed that Rspo2 is requisite for normal development of several tissues, including craniofacial structures, lung, kidney, and limbs [ 27].
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Differential gene expression is a pre-requisite for normal and abnormal cellular/physiological events.
Thus, we demonstrate that Fz2/Ca2+ transients during development serve as a pre-requisite for normal adult behavior.
Sensitivity to the attentional states of others has adaptive advantages [1], and in social animals, attending to others is important for predator detection, as well as a pre-requisite for normal social functioning and more complex socio-cognitive abilities [2].
It has recently been shown that localized F-actin remodeling is a requisite for the normal biphasic pattern of nutrient-stimulated insulin secretion.
Because commitment to the disciplinary matrix is a pre-requisite for successful normal science, an inculcation of that commitment is a key element in scientific training and in the formation of the mind-set of a successful scientist.
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CEO of Professional Science Editing for Scientists @ prosciediting.com