Given that cell rolling is a pre-requisite to firm adhesion for systemic cell homing, we examined the potential of immobilizing sialyl Lewis X (SLeX) on mesenchymal stem cells (MSCs) to induce cell rolling on a P-selectin surface, under dynamic flow conditions.
Requisite integrin recycling during cellular adhesion is becoming increasingly recognized [17], [32].
Although these data demonstrate that the actomyosin cytoskeleton maintains polarized morphology and requisite tension necessary for durotaxis, focal adhesion complexes at the leading edge of cells likely establish critical intracellular signaling gradients for durotaxis.
In addition, EcN adhesion capacities were tested as possible requisites for an EcN specific probiotic activity.
The adhesion is thought to be a pre-requisite for differentiation to the infective form, but less is known about how epimastigote adhesion triggers the differentiation process after the nutritional stress [40].
This leads to activation of integrin α2β1 which then allow stable adhesion and facilitate spreading [29], a pre-requisite to thrombus formation [30].
DOI: http://dx.doi.org/10.7554/eLife.06638.002 For commensal and pathogenic bacteria, adhesion to host surfaces is a pre-requisite for colonization and infection, and is mediated by surface-presented adhesins (Pizarro-Cerdá and Cossart, 2006).
Consistent with these requisite cellular processes, CTGF has been shown to promote endothelial cell adhesion, migration and proliferation in culture and to induce angiogenesis in vivo (Kireeva et al., 1997; Shimo et al., 1998, 1999; Babic et al., 1999).
A potential mechanism by which the MAP kinases mediate the effects of TGF-β1 is through the cell cell adhesion molecule N-cadherin, previously shown to mediate embryonic mesenchymal condensation, a requisite cell cell interaction in developmental chondrogenesis [ 106- 108].
Patterned adhesion of neurones and directed growth of neurites is the pre-requisite to establish meaningful in vitro models for the study of interactions and signalling between neurones.
