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He returned to England on the support vessel, although the homeward voyage was delayed after Valorous struck a reef and required substantial repairs.
Given that targeted DNA repair requires substantial flexibility of DNA ends, these observations raise the possibility that the dynamic anchoring of axis proteins may also be an important prerequisite for controlled meiotic recombination.
The repair of craniofacial bony defects by traditional grafting techniques requires substantial time and effort, with associated morbidity.
Furthermore the definition of efficient manufacturing routes with respect to tolerance compliance requires substantial investigation and, though the Launcher is designed for ITER lifetime, potential repair by adequate remote handling procedures must be considered.
The recruitment of sufficient numbers of patients to achieve statistical power, the development of reliable methods to measure the bone repair endpoint, and the randomization of patients to treatment groups in an ethical experimental design require substantial thought and planning.
Such extensive activity requires substantial funding.
This may require substantial changes in personnel.
Big changes, however, will require substantial investment.
All of them require substantial expenditures for required maintenance.
This simulation requires substantial computational power.
It will require substantial forces and substantial time to put those forces in place to move.
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CEO of Professional Science Editing for Scientists @ prosciediting.com