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The comparison of the back-translation and the original MSSS-88 questionnaire identified 19 items requiring refinement, which were discussed with key MS opinion leaders.
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BACKGROUND Transcatheter heart valve (THV) sizing algorithms are device specific, requiring refinements for new valve designs.
The system is easier to use (though still requiring refinements) and allows GPs to undertake actions such as sharing information with Out Of Hours services without needing to frame those actions in terms of palliative care.
There are certainly still fundamental flaws to Morris' game that require refinement.
However, the unbounded FIFO based asynchrony is not realizable in practice and hence requires refinement in real hardware.
Application of this therapeutic modality to neurodegenerative lysosomal diseases requires refinement of neural cell targeting and CNS delivery methodologies.
Improving pre-clinical models by the research community is one aspect of the drug development pipeline that will continue to require refinement.
Field validation demonstrated that previously developed coarse-scale models were moderately successful in predicting loess thickness, but these models required refinement.
Experts said the findings were striking and ingenious, but required refinement before they could become a cancer test.
While they succeeded to an extent, it's important to remember this is still 1.0 technology and it's going to require refinement over time.
Those points required refinement and even re-formulation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com