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The major toxicity of high dose cyclophosphamide was hematopoietic, with one patient requiring a dose reduction after three courses due to prolonged thrombocytopenia.
Pharmacokinetic results were as predicted for emtricitabine, didanosine, and efavirenz capsules, whereas efavirenz concentrations in children receiving efavirenz oral solution were lower than anticipated, requiring a dose escalation after the planned assessment point.
As VS is primarily eliminated through the liver into the bile and feces, patients with obstructive liver disease are more susceptible to its toxic effects, requiring a dose reduction depending upon the serum bilirubin concentration.
The drug interaction profile of DTG is characterised by few drug interactions requiring a dose adjustment.
The most common toxicities were skin rash (35%) and fatigue (33%), requiring a dose reduction in 22% of patients.
Of the 10 patients requiring a dose reduction of T-DM1, dose was reduced to 3.0 mg/kg in 8.
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Some lack confidence and require a dose of reassurance.
This state's dysfunctional, tribal political culture sorely required a dose of vision and gravitas.
Only six patients (6%) required a dose adjustment.
It was all looking elegance itself until it required a dose of Josh Lewsey to finish things off.
An interim analysis performed in August 2003 revealed that 32% of patients required a dose reduction of oxaliplatin because of toxicity.
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CEO of Professional Science Editing for Scientists @ prosciediting.com