Pedestal formation requires virulence-related EHEC proteins to be injected directly into the host cell through a type III secretion system (TTSS) [8].
Bacteria require virulence factors to colonize, multiply and survive in the udder.
Challenge strains should also express the required virulence characteristics and share features consistent with other circulating strains, which will allow study findings to be applied to contemporary field settings.
The response of the leuO promoter to butyrate requires two virulence regulators, Pch and Ler, in addition to Lrp.
S. flexneri requires the virulence factor invasion plasmid antigen B (IpaB) to invade host cells, escape from the phagosome and induce macrophage cell death.
The production of 1-TbAd requires the virulence-associated enzyme Rv3378c.
Therefore, some F. tularensis factors required for virulence in mammals are also required for virulence in the arthropod model system, but there are distinct molecular differences utilized by F. tularensis to exploit the two hosts [22], [23].
Here we show that unsaturation in C8 and methylation in C9 is required for virulence in the mouse model without affecting fungal growth in vitro or common virulence factors.
Virulence studies utilizing systemic models of infection showed that a full-length RopB was required for virulence.
CPS is required for virulence of bacteria and variation in CPS content may contribute to the differences in virulence among A. pleuropneumoniae isolates [38].
To identify genes required for virulence that could be used as targets for novel treatments, we mapped quantitative trait loci (QTL) affecting virulence in the progeny of a cross between two strains of A. nidulans (FGSC strains A4 and A91).
