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In the words of Marzagalia, echoing Dietrich Munz: "It requires stepping up the game.
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Co-founder Bas Lansdorp said: "We will be landing from 6km lower than Curiosity, so we will be going slower, meaning the required step-up in technology is about 66 per cent".
Two patients were treated with dose escalation of existing medical therapy, whereas others required step-up therapy to immunomodulators or anti-TNF therapy.
If left without any maintenance drug, about 70% of patients will relapse within 12 months (2), and many patients on maintenance drugs will still require step-up therapy.
Lambert says it is perfectly possible Davis wasn't aware she had to pay more into her pension to receive the much higher death-in-service lump sum, adding: "My sister was struggling to support her children on a low wage and would have had little spare income to pay the required Step Up contributions".
The young players were required to step up, and they played a gritty two-way game.
Now that they are locked into the euro, they are required to step up with a more painful process of wage and job cuts to restore competitiveness.
As more women re-enter the workforce and build their muscle as breadwinners, more men will be required to step up on the home front – and it's here they find themselves facing the exact dilemma that has traditionally faced women: By declaring my desire to become more hands-on the home front, do I risk being seen soft or less serious about my career?
This required a "step up" in technology, he explained.
"They both have a very good feeling for this club and know what is required to step up and lead from the front".
And with the Magpies squad tested by European and domestic commitments, Pardew has already reassured his squad they will be required to step up.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com