However, because anti-malarial treatment at the blood-stage requires rapid intervention, we focused on the dominant, blood stage-specific cytoplasmic ribosome from the most virulent form of Plasmodium, P. falciparum (Pf80S) (Waters et al., 1989), as inhibition of cytosolic translation would be expected to be direct and fast-acting.
An oncological emergency can be defined as an acute, potentially life-threatening condition in a cancer patient, either as a direct or indirect effect of the underlying malignancy or secondary to its treatment, requiring rapid intervention to avoid death or severe morbidity.
The main objectives were the early detection of emergencies that might require rapid intervention and the coordination of corrective actions.
A recent systematic review of complications arising from TRUS-Bx found that, although symptoms of minor bleeding or urinary complications are common, they do not usually require intervention; infective complications, though uncommon, can be serious and require rapid intervention [ 4].
Acute compression of the spinal cord by a tumour requires rapid neurosurgical intervention.
Cerebral tuberculosis infection is a fatal situation that requires rapid medical intervention; one of the drugs used in this case is IV RIF; however, the drug cannot pass the blood brain barrier (BBB) completely and the therapy is troublesome [22].
The Global Burden of Disease Study proposed that COPD, which was the sixth leading cause of death in 1990, will become the third leading cause of death by 2020. 3 4 Acute exacerbation of COPD (AECOPD) is an emergency that requires rapid medical intervention, and a significant proportion of patients with AECOPD require tracheal intubation and admission to the intensive care unit (ICU).
A perforated peptic ulcer is one such possibility and requires rapid diagnosis and prompt intervention to avoid the associated high risk of morbidity and mortality.
Pre-hospital bleeding not controlled by compression and splintage requires rapid surgical or radiological intervention.
See related commentary by Geeraerts et al., Elevated intracranial pressure (ICP) is a common manifestation of severe brain injury that requires rapid diagnosis and therapeutic intervention [ 1, 2].
During the course of these RCTs it is common for clinical exigencies to emerge that require rapid, direct intervention.
