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Eleven patients (73%) received two cycles of chemotherapy without dose modification and four patients (27%) required dose modification due to toxicity.
Overall, more than one third of patients required at least one treatment modification due to an AE in the first 24 weeks of treatment and there was a statistically significant inverse correlation between AEs and dose intensity.
Regimen modification due to treatment failure has a different mechanism.
In contrast, the newly proposed GBS-type ONPP does not require going through significant design modifications due to inherent characteristics of the construction method.
Dose modifications due to toxicity were required in 19%% of patients; the type of modification was not specified.
These cytoskeletal and adhesive events did not require new protein synthesis, this being consistent with functional protein modifications due to alteration in phosphorylation.
Treatment-related adverse events and therapy modifications due to toxicity were not collected.
Rules for environmental modifications due to the earthquake are proposed.
It requires modification of existing screens.
Other components might require modification to better optimize their definitions.
The need to restore control requires modifications of open grid streets.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com