The House measure, the most far-reaching piece of energy and environmental legislation to come before Congress in years, would require large changes in the way the United States generates electricity, manufactures products, heats and lights its homes and offices, and moves people and goods.
As January comes to a close, many of us will give up on our resolutions because they're too lofty of goals or they require large changes in our daily lives.
In this model, small signals require large changes in binding quantity to reach the same level of significance.
Several biocompatible hydrogels were screened, although those requiring large changes in temperature, pH, or ionic strength to gel were excluded as they might compromise the vesicles.
The implication of this concentration difference is that small perturbations in sgp130 level have minimal effect on system dynamics, and any observable effects require large changes in sgp130.
Change in gene function might not necessarily require large changes in evolutionary rate or amino acid sequence however, with more subtle changes in sequence or regulation also able to bring about functional change.
In conclusion, a comparison of the genomes of 2 closely related organisms, unicellular Chlamydomonas and multicellular Volvox, highlighted that the transition from unicellular to multicellular life does not require large changes in gene content.
But if the program is attracting a broader constituency, then demand for benefits could grow more rapidly, requiring larger changes.
Estimates of minimal clinically important improvements (MCIIs) are larger among patients with higher values at baseline, suggesting that these patients require larger changes to appreciate improvements.
First, studies using BI-RADS and Wolfe classification patterns capture variation in the extent of mammographic density across only four categories; therefore, studies using these categorical measures of mammographic density require larger changes to reflect a categorical change.
