Sentence examples for requires increased levels from inspiring English sources

Cell count, being one of the most fundamental measures for cell-based therapeutics, now requires increased levels of measurement confidence.

In an effort to identify signaling molecules underlying the role of Crif1 in AD pathogenesis, we also found that A β-induced downregulation of Crif1, requires increased levels of ROS.

Indeed, a recent study involving conditional mouse models has shown that BRAFV600E cooperates with the loss of PTEN in the induction of metastatic melanomas [ 221], which underscores the idea that BRAFV600E requires increased levels of PI3K activity to drive malignant melanomas.

[ 2] There are no treatments that can cure, delay onset or slow the course of HD; from onset onwards progressive degeneration occurs and the sufferer requires increasing levels of care and maintenance [ 2], but provision of a "full range of supportive medical nursing and social care" can help improve the patient's quality of life [ 28].

Different characteristics of extracted nucleic acids may be viewed as important in studies with different aims (for example, some may require increased length of amplicon, while others may require increased effective amplifiable copy number, while others may simply require increased levels of extracted nucleic acids).

They are also less likely to get home if they are socially isolated and require increased levels of social care.

Because IECs are rapidly proliferating at larval stages (Fig. 3A), they might require increased levels of de novo PI synthesis.

Interestingly, cancer progression is identified with rapidly proliferating cells which require increased levels of protein synthesis and processing (Luo & Lee, 2013), resulting in activation of the UPR.

The modified early warning system (MEWS) is a physiological scoring system that identifies patients at risk of deterioration who require increased levels of care [ 1].

The biological significance of this finding remains to be determined, but could indicate that malignant B-cell lymphomas produce greater amounts of polyubiquitinated and misfolded proteins than normal B cells, therefore requiring increased levels of VCP expression to ensure their proteosomal degradation, reduce ER stress and avoid undergoing apoptosis.

These data allow us to speculate that the MEK inhibitor, AZD6244, may be an attractive drug to target the luminal (and perhaps other) breast cancer TICs in any cells in which MEK/ERK signaling is active, but that Six1 overexpressing cells may require increased levels of the drug to accommodate the enhanced MEK/ERK signaling observed in those cells.