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Longer anesthesia time requires higher doses of anesthetics, opioids, and neuromuscular blocking drugs.
This will also help clarify to what extent sublingual immunotherapy requires higher doses of major allergen.
Patients with Paget's disease were also excluded as their treatment requires higher doses of bisphosphonates and for much longer periods.
Recovery from maladaptive interpersonal patterns, for example, typically requires higher doses of psychotherapy than does recovery from symptoms of depression or broader distress [ 25].
However, this requires higher doses of aspirin (Thun, 2000), as shown for colorectal cancer in several previous studies (Thun et al, 1993, Collet et al, 1999), including one within this NHS cohort (Chan et al, 2005).
COX-2 is less sensitive to aspirin because inhibition of the inducible COX-2 requires higher doses of aspirin and shorter dosing intervals as nucleated cells can promptly resynthesise the enzyme.
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Using XR as a light source requires high doses of protoporphyrin IX (PpIX) and XR irradiation.
Full deprotection therefore requires high doses of UV irradiation.
10.7554/eLife.05165.005 Figure 3. Pre-erythrocytic immunity following CPS immunization requires high doses of sporozoites.
For this reason, induction of hypothermia in younger patients often requires high doses of sedation drugs to neutralise the counter-regulatory mechanisms [ 72].
Consequently, this requires high doses of vector particles, increasing the risk of immune responses against the vector and/or the gene-modified cells.
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