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Since ACTRIIB receptor mutation also inhibits BMP7-induced repression of the hTERT gene promoter albeit to less degree than that of BMPRII receptor, we cannot exclude a possibility that ACTRIIB receptor is also involved in mediating BMP7 negative regulation of telomerase activity which requires future studies.
Disentangling these different effects of outbreeding requires future studies.
The mechanism by which PGRN haploinsufficiency in FTLD patients leads to altered miRNA expression is currently unclear and requires future studies.
While the difference between rat and human disc tissues requires future studies using different species, investigation of distinct response in the rat model provides fundamental information to elucidate a specific regulatory pathway of TGFβ1.
In addition, clarification of the mechanism by which shPLB-RNAi is linked to the changes in miRNA-1 and miRNA-133 (passive association or component of the therapeutic process) requires future studies.
Although this study was hypothesis driven, we emphasize that verification requires future studies in which the entire right and left temporal lobes of forensic infant autopsied cases are examined in serial step sections with precise matching of anterior to posterior levels, and in depth immunocytochemical studies to characterize cell markers of interest.
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An accurate method for measuring the Young's modulus also requires future study.
Cognitive training of this type may hold promise as a novel intervention for reducing PTSD symptoms, although the mechanism of action and implications for models of PTSD requires future study.
The manner in which seasonality affects the transmission pattern of BBD and the rate of new infections is not fully understood and requires future study, and is undoubtedly complex as in many other seasonally forced diseases [49].
The relationship between Aplnr signaling and cBAF function requires future study.
Second, this finding may also demonstrate a problem in the process of care which requires future study.
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