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This requires further trials [ 3].
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The data for perinatal mortality associated with extra-amniotic prostaglandins are extremely limited and require further trials [ 92].
The clinical proof of superiority of extended or continuous infusion of betalactams or vancomycin is suggested by few studies [ 64, 67– 71], and required further trials.
Hence, a thorough assessment of the benefits of metformin- DRP/EE30μg therapy on vascular function require further trials that should include a weight loss group as a control arm.
The reduced rates of induction of labour are of interest and require further trials reporting labour induction rates with sufficient power to detect differences in subsequent perinatal outcomes.
Whether the fluid imbalance was the result of more severe renal failure or whether it contributed to its cause requires further clinical trials to elucidate.
To have full confidence that these interventions are widely effective requires further well-conducted trials from different settings.
The role of VEGF in the pathogenesis of uveal melanoma requires further clarification, but trials of anti-angiogenic agents of patients with melanoma, including uveal melanoma, are underway.
Targeting TNFα may be of therapeutic benefit in OA and requires further evaluation in controlled trials.
Whether there is residual confounding due to indication for fluid use or unmeasured risk factors requires further investigation in controlled trials.
The causal relationship cannot be implied but as we stated the findings will provide knowledge about areas that requires further evaluation in clinical trial setting.
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