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On the other hand, reprogramming gene expression during ZGA and MGA requires considerable changes in chromatin structure (14– 16), and modulation of chromatin folding affects access of regulatory factors to their cognate DNA-binding sites.
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However, these composition changes also affect the cathode properties and may also require considerable changes in the processing conditions.
"Developing teachers' capacity to enact new standards in ways that support the intended student learning outcomes will require considerable changes in mathematics instruction in our nation's classrooms.
103 Approaching the topic through coordinated, international action will require considerable changes in many current national and regional health strategies and disease-control policies.
Second, ward staffs' enthusiasm for involving volunteers in a more focused and direct role with patients was seen to require considerable change in the way volunteers were currently deployed.
Action involves the most overt behavioral changes and requires considerable commitment of time and energy" (Norcross et al, 2011).
However, because adequate diabetes self-management (DSM) may require considerable lifestyle changes to several domains, namely having a healthy diet, exercising, or glucose monitoring, not all the patients are able to properly follow the self-management plans agreed with their healthcare professionals or advised by clinical guidelines.
A whole-of-institution response to aligning a business with the two degree Celsius target requires considerable research and policy development and fundamental changes to business as usual.
This change is not easy, and it requires considerable determination and continuing input from senior staff to embed and maintain it.
Quantification of changes with digital image analysis is also costly and requires considerable expertise.
Successful implementation of any reform, however, requires considerable planning, advertising and convincing of staff and students of the need for and the benefits of change [ 4- 9].
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