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A successful Zika virus vaccine requires challenge experiments that are done at long intervals after immunisation and that identify protection as the absence of viraemia and the absence of an anamnestic antibody response.
The brain is a plastic organ and requires challenge, critical thinking and structure to stay healthy and active.
The notion that fluoroquinolone therapy can be "targeted" for an indication requires challenge as fluoroquinolone therapy will always result in systemic drug levels.
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It's scary to admit that the problem reaches beyond the glare of our laptops and phones, and accept that dealing with it requires challenging the very roots of society.
There is enough wealth in the country to achieve all of this but it requires challenging the power of concentrated wealth.
This change required challenging the traditional roles of solo practitioner, data collector, and keeper of infection control data and knowledge.
It will require challenging their ideology and dismantling their recruitment infrastructure.
Details of levels of skills, support required, challenging behaviour, and other symptoms were sought.
The future of the NHS requires the challenge to be met in full.
Tailoring nanoparticle architecture requires the challenge of reproducibly manipulating and controlling assembly at the molecular level.
Implementing this strategy requires overcoming challenges in predicting both power prices and water inflows.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com