The values shown in Fig. 19 also illustrate a high discharge variability at the beginning of the rainy season (December) leading to a challenging plant operation (requirement of frequent readjustments of the plant's settings).
But natural repellents as essential oils are the upcoming genre of scientific interest due to their non-toxic, non-sticky, non-irritating and eco-friendly nature; however, essential oil repellents tend to being short-lived in their effectiveness due to their high volatility and requirement of frequent re-application.
Though schistosomal parasites are sensitive to the treatment of praziquantel, high re-infection rates in both human and animals plus the requirement of frequent administration still limit the overall success of chemotherapy.
These reasons were justified given the elderly study population with multiple comorbidities and the study requirement of frequent travel to the intervention site.
Despite the availability of a highly effective chemotherapeutic drug (Praziquantel), the high re-infection rates in humans and animals plus the requirement of frequent administration of the agent still limits the overall success of chemotherapy and disease control efforts.
However, these drugs suffer from poor efficacy because of viral resistance mutations, the requirement of frequent intravenous injection, or severe dose limiting side effects such as myelosuppression or nephrotoxicity.
These include the requirement of frequent and repeated visits of millions of women with a normal cervix, the 4 5% uncertain cytological results (ASCUS and others) requiring additional diagnostic protocols, the often required biopsies and the eventual surgical treatments for conditions that otherwise would regress spontaneously in a sizeable proportion (i.e., most of the CIN 2 cases).
The phylogenetic distribution of intron sequences by geographic location is consistent with the hypothesis that once a homing endonuclease becomes fixed in a genome, selection pressure for the gene significantly decreases resulting in degeneration (mutation) and enforcing the requirement of frequent horizontal transmissions between populations to maintain intron propagation [ 34].
This certainly is consistent with the chronicity of this disorder and the requirements for frequent surgical revisions.
Both can be self-administered at home, but they have some disadvantages, including the requirement of more frequent administration and the risk of pain and local site reactions.
