Given the high level of conservation of these individual binding sites, there appears to be strong evolutionary selection for a particular HD-preferred sequence, a process that may be driven by the requirement for maintaining essential interactions with other TFs in a given regulatory context.
This position also requires interaction with other departments within the company to give advice on regulatory guidelines and requirements.
These studies showed that ATase and NRII differ in their requirements for interaction with PII, and that under the appropriate conditions, the antagonism between α-ketoglutarate and ADP allowed each of these effectors to influence the binding of PII to receptors.
Aspergillus fumigatus HapX, 491 amino acid residues in length, contains the following domains: a "b ZIP)" basic and a "coiled-coil" domain, which together mediate DNA-binding in bZIP-type transcription factors, and an N-terminal CBC-binding domain that is essential for HapX function due to its requirement for interaction with the CBC subunit HapE (Hortschansky et al, 2007).
The proximal binding of Sp1 to the TSS has been demonstrated to be a requirement for positive interactions with the ER to enhance transcription and also to stabilize weak interactions of ER [ 47].
Mono- and bis-benzo[b]oxepine derivatives have been rationally synthesized to meet the molecular requirement for interaction with estrogen receptor.
Isoprenylation allows ras to approach the membrane, a requirement for interaction with the EGFR.
IGFBP-2 contains an integrin recognition sequence, RGD, near the COOH C-terminus, which is the minimum requirement for interaction with integrin receptors.
However, some features of the peripheral location itself will influence its peripherality, as these will impact on its requirement for interaction with the main centre.
The important functions and complex structures of these multimeric proteins, along with the requirement for interaction with numerous client proteins, have evidently severely constrained the divergence of sequence over vast periods of time.
