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During the 7 days of inpatient study, APAP-ALF patients with ICH/CE had higher requirements for ventilation (MV 100 vs. 75%, p < 0.0001) and were more likely to achieve high (3 or 4) HE coma grade (100 vs. 72%, p < 0.0001).
All of them lead to lower VdAS/VtA and reduced requirements for ventilation.
Although it is hazardous to extrapolate from the available data to the clinical setting, taking measures to lower vascular stress (e.g. by reducing the physiologic requirements for ventilation and cardiac output) is a logical, but as yet unproven, extension of a lung-protective strategy for life support in ARDS.
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The same pattern was seen for requirement for ventilation.
cMultivariate analysis using trauma, requirement for ventilation and temperature characteristic as independent variables.
Other persistent independent risk factors of mortality were PRISM score (highest tertile), requirement for ventilation and documented infection.
In the intention to treat analysis for secondary outcomes, we found no significant differences between treatment arms for length of hospital stay or requirement for ventilation for all patients or the subgroup with confirmed chronic obstructive pulmonary disease (table 3).
To fulfill the condition for severity, patients must either meet both the major Infectious Diseases Society of America/American Thoracic Society criteria (shock or requirement for ventilation) or have one major criterion or at least two minor ones.
We found no significant differences between treatment arms in length of hospital stay or requirement for ventilation for all patients or the subgroup with confirmed chronic obstructive pulmonary disease (table 4).
Patients treated with eculizumab still developed new complications, such as seizure or requirement for ventilation, and in more than 40% of the patients plasmapheresis was continued after eculizumab had been started.
15 More recently, audits of hospital management have shown that the administration of high flow oxygen during acute exacerbations of chronic obstructive pulmonary disease has been associated with increases in mortality, length of hospital stay, requirement for ventilation, and admission to high dependency units.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com