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Furthermore, most of the patients for whom clinical follow-up data were available showed a progressive disease course with increasing levodopa requirements, emergence of motor complications due to chronic treatment with levodopa and presence of classic non-motor features of Parkinson's disease, strongly supporting nigrostriatal cell loss as the underlying pathology.
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Integrating these individual-level processes into a mathematical model of P. falciparum transmission, we refine the requirements for the emergence of realistic variation in VSA expression at the population level.
The act of formulating the model as analytical expressions helped us in decoding the minimal requirements for the emergence of these criteria more precisely than with our former computer simulations [12] and lead to a generalized understanding of cell front organization untied from the specifics of any cell type's molecular inventory.
Experimentally validated computational models have the capacity to generate quantitative predictions and establish the minimal requirements for the emergence of biological phenotypes.
The requirements for the emergence of a primitive, coupled replication-translation system, which is considered a candidate for the breakthrough stage in this paper, are much greater.
We discuss the signalling requirements for the emergence and differentiation of the NMp, and also the role that 3D structures might play in its maintenance.
It also offers a quantitative calibration on the requirements for the emergence of various outcomes by examining the effects of inhibition, relative growth rate, and population diffusion.
Plant species distributed in arid and semi-arid areas, where precipitation is unpredictable and the amount is low, have special drought tolerance requirements during seedling emergence (Zhu et al. 2014).
However, studies investigating the functional ablation of βIII-tubulin functions in this setting are required to demonstrate conclusively its functional requirement for the emergence of castration-resistant tumours.
The initial requirement for the emergence of CMV-specific CD8+ T cells is poorly understood.
We conclude that climate change is probably the most important requirement for the emergence of arthropodborne diseases such as dengue fever, yellow fever, Rift Valley fever, Japanese encephalitis, Crimean-Congo hemorrhagic fever, bluetongue, and African horse sickness in the United Kingdom.
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