Total fentanyl requirement (dose and time) was recorded.
Conversely, other investigations report beneficial effects of NHPs including lowered requirement doses of medications [ 14- 17].
In kidney recipients, CYP3A5 genotype was significantly associated with median tacrolimus dosing requirements, number of dose changes, and concentration/dose ratio (Table 3).
Protecting this vulnerable population would require a massive increase in vaccine production, which currently is achievable only by dramatic reductions in antigen requirements per dose (2).
Along with the development of G-CSFs, advances in cancer care have been accompanied by reduced requirements for dose reduction and delay due to FN.
Most countries visited were not well informed about the multiple presentations (number of doses per vial, cold storage requirements, recommended doses per child, etc).
Reduced bulk vaccine requirements with dose-sparing adjuvants could make the capacity to fill and distribute vaccine doses a limiting factor.
However, a fundamental clinical question arose surrounding opiate requirements and dosing management.
The primary study measurement was the change in the effective exogenous insulin requirement (daily dose and duration of usage).
(11) These irreversible inhibitors have shown substantial toxicity, with a resultant requirement for dose reduction in phase 2 and 3 trials.
Monitoring of rFVIIa efficacy should therefore be performed visually to assess the level of bleeding after rFVIIa administration, and by an assessment of the transfusion requirements after dosing.
