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Translational research can be impeded by cumbersome regulatory requirements, difficulties obtaining samples, and challenges pinpointing the mechanisms underlying disease processes and therapeutic effects in human beings, whose genetics, environments, and behaviors cannot be tightly controlled.
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Evolving requirements present difficulties, especially in environments in which business agility demands shorter development times and responsive prototyping.
The research identified the process undertaken to define new requirements, the difficulties faced by the various parties involved and the impact these had at the front-end.
Lack of fully specific targets, along with selection of targets with spatial and temporal expression well aligned to interventional requirements, pose difficulties to this process.
Fully-integrated surface-subsurface modelling has shown potential in increasing process understanding for runoff generation, but high data requirements and difficulties in model calibration are typically assumed to preclude their use in catchment-scale studies.
Caution is advised for more evidence before it becomes routine considering resource requirements, practical difficulties and consequences [ 7].
Product proliferation and demand uncertainty result in material requirement planning difficulties, which give rise to high inventories and low customer service.
Five previous attempts to mount it had been called off, casualties of its elaborate technical requirements, daunting difficulty and four-hour duration.
This requirement imposes difficulties in integration into an existing control system that typically has resources dedicated solely to control applications.
However, others have called for more evidence before implementing such a policy change, citing concerns such as increased cost for materials and training, higher biosafety requirements, and difficulty standardizing techniques across sites [ 16].
Educational materials must be culturally relevant and language appropriate: tailoring materials to reflect country-specific health care realities [ 20], gathering challenging, real-world cases despite often incomplete content [ 42, 45], and uncertainty about language requirements or difficulty expressing thoughts in another language with the same message as in one's own language [ 43].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com