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It's unclear how these features of rational requirements could be explained by a view that takes them to be merely evaluative.
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The observed sex-specific effects of mtDNA on phenotypes, visible at least in the between-population analyses carried out here and in another study [ 46], could be explained by different requirements between sexes connected to their reproductive biology [ 8, 47].
These results could be explained by a requirement for strain familiarity or individual familiarity.
This could be explained by the requirement for Tipin in promoting Polα binding to chromatin.
The ATI-AS coupling in 5′ UTRs could be explained by the requirement of short 5′ UTRs for efficient initiation of translation (Wegrzyn et al. 2008), so that utilization of an upstream transcription start is compensated by AS.
IL-10 is known to repress IFNβ induction in response to LPS [35,36], thus the results in Fig 1E could be explained by a requirement for IFNβ for sustained MCP-1 mRNA induction.
This could be explained by large input requirements for gas and electricity per unit of output.
ATP synthase was detected as differentially expressed which could be explained by the high requirement of energy needed to quickly reorient in space.
A comparable decrease was observed in mice treated with JAKi, which could be explained by the critical requirement of IL-2/JAK1&3/STAT5 IL-2/JAK1&3/STAT5 maturation of FOXP3+ Tregsignaling7].
A decrease in the ribosomal requirement for protein production with an increase in the growth rate could be explained in terms of the disposal soma theory.
Both the weaker repression at ura4 and ade6 in the swi6∆ B-box double mutant could be explained if in our reporter system the requirement for Swi6 in heterochromatic silencing is not bypassed fully.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com