However, it is important to make a quantitative comparison between this change in [Ca 2+] NJ and the [Ca 2+] i requirements to activate the putative RyR3 population of the junctional SR.
In contrast, by analyzing the initial phase from ED admission to ICU admission, our study focused primarily on the first hours because this is clinically the most important phase to detect transfusion requirements and to activate blood bank resources and massive transfusion protocols.
Thus, the requirement for oligomerization to stabilize SpoIIE in the forespore can be uncoupled from the requirement for oligomerization to activate σF.
Taken together, these results demonstrate the requirement of Rb to activate NF-kB in response to VSV infection and point to PKR as a possible mediator.
It is conceivable that the up-regulation of these genes is related to the requirement of copper to activate oxidases involved in iron assimilation.
The induction of pkn22 expression in response to 1 h H2O2 stress was abolished in the CSE2 strain (Fig. 2b), indicating a requirement for NtcA to activate pkn22 transcription under this condition.
A similar stringent requirement for Bax to activate the intrinsic pathway of apoptosis has been demonstrated for human colon cancer HCT116 cells (Zhang et al, 2000; LeBlanc et al, 2002).
Having established the existence of a chiral binding site for PS activation of TRPM3, we sought to identify further structural requirements for steroids to activate TRPM3.
We have considered the possibility that the effects of LKB1 deletion reflect the requirement for this enzyme to activate AMPK.
Since we have now shown that both Aβ and NGF deprivation induce caspase 2 activity and require caspase 2 to execute death, we used several approaches to study the requirement for the PIDDosome to activate caspase 2 in neurons.
