The method ATP combines the intended purpose and the ICH Q2R analytical method quality requirements: specificity, precision, accuracy, linearity, range, quantitation limit, and detection limit.
The requirement for specificity in the C-terminal domain is perhaps aided by the disordered, extended nature of the C-terminal residues of the antitoxin sequence and structure plasticity.
This suggests that the requirements for malaria vaccines are not completely unique, but that the general requirements need specificity to the context of malaria vaccines.
The method was developed and validated according to ICH requirements for specificity, linearity, accuracy, precision (repeatability and intermediate precision), LOD and LOQ.
a. paratuberculosis) can be divided into two major strains, sheep (S) and cattle (C), based on cultural requirements, host specificity, degree of clumping of cells in suspension and minor genomic differences including copy number of insertion elements and point mutations.
However, due to the differences in nutritional requirements, growth specificity, inheritance characteristics and activities of the secreted extracellular enzymes among edible fungi (Montoya et al. 2012; Yang et al. 2013a), differences exist in the utilization capacity of the different crop straws.
An optimized antibody fragment designed for targeting cancer in vivo should fulfill several requirements: high specificity and affinity for the target antigen, low immunogenicity; and be ready available form expression to purified protein [1].
The result (1) was first derived in the context of selectivity of energy requirements and specificity of energy disposal of chemical reactions [ 25, 28].
For field diagnosis, the optimal detection system should be economical, quick, and easy to operate, moreover should meet the requirements of specificity and sensitivity [ 38].
Other dimensions might be included (eg., restrictions on time, place, or clinical environments), but it is the explicit and unambiguous definition of each of the four basic dimensions that fulfils the requirements for specificity [ 7].
