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This is a key issue as the requirement of "cold chain" distribution increases costs and inherently limits the availability of therapies throughout the developing world. 2 Transcutaneous therapeutic administration also has the potential to enhance the clinical effectiveness of treatment, by allowing for more efficient delivery of drugs susceptible to first-pass metabolism in the liver.
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Besides, the strict requirement of cold-chain during transportation and storage make its application in low resource settings to be inconvenient.
The proposed method optimally schedules ES devices to minimize the total operating costs while satisfying the load requirements of cold, heat, and electricity in microgrids.
The detector fulfills all the requirements of cold fusion experiments and, on the other hand, can operate in several kind of experiments involving neutron detection, even when significant, variable and not taggable background is present.
The oxygen requirements of cold and deep-living species do not appear to be elevated (Childress et al., 1990; Peck & Conway, 2000; Drazen & Seibel, 2007; Seibel & Drazen, 2007) suggesting they are functionally adapted to high hydrostatic pressure and low temperature (Childress, 1995).
Further research into the nutritional requirements of cold-water scleractinians is required to satisfy these hypotheses.
However, based on our studies with the recD mutants of Antarctic P. syringae it was not clear whether RecD requirement of the cold-adapted bacterium at low temperature is due to the functional inactivation of RecBCD complex or of the RecD protein alone [6].
Requirement of a cold-chain, however, complicates stockpiling and the logistics of vaccine distribution.
This period between a non-vernalized and vernalized state, which is critical for the plant's ability to flower in view of its obligatory requirement for cold, was characterized by major changes in gene expression (Fig. 3), which therefore might be related, among other processes, to the flowering mechanism.
To fulfil the temperature requirements of the cold chain, the fresh fish are usually packed, stored and transported to fish markets with ice in open styrofoam boxes.
In the past, people opposed empires, colonial powers, and the ideological requirements of the Cold War by banding together in more compact nation-states.
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