Sentence examples for requirement of binding from inspiring English sources

However the requirement of binding to DNA introduces a restriction on the possible arrangement of the components such that the protein-protein binding may be weakened by this extra strain but the additional synergistic stability of the three way complex more than compensates for this effect (Table 5).

By association with Aha1, Hsp90α may bypass the requirement of binding TPR domain containing co-chaperones, since secreted Hsp90α contains a truncated C-terminal domain, which is required for TPR-binding.

The detailed analysis of the designed peptide interactions and comparison of those peptides with the known peptides indicate that our method is able to detect the requirements of binding surface; such as hydrophilicity, electrostatic compatibility, aromatic interactions, sulfur atom and its interactions.

We next investigated the requirement of CXCR3 binding for CXCL10's anti-proliferative effect on HUVEC utilizing a series of CXCL10 mutants we previously described [28].

An assessment of the requirement of the binding site for activation is needed.

The ATPase domain interacts with Ire1 exclusively, without the requirement of substrate binding domain.

Dose response curves were also used to assess the requirement of membrane binding for Bcl-XL activity.

We reasoned that the F266A mutation offered an experimental strategy to isolate the requirement of lncRNA binding for WDR5 function.

A requirement of transient binding means that dissociation kinetics are selected to be just fast enough, not as slow (corresponding to very stable complexes) as possible.

This phenomenon was confirmed as well by Barleon et al [ 36], revealing the requirement of VEGF binding for the first three Ig-like domains.

To test the requirement of DNA binding to promote extensive telomere elongation in the presence of a Cdc13– Est2 fusion, we made use of a previously characterized DNA-binding-defective allele of Yku70, yku70 -R456E (Lopez et al. 2011).