Our interpretation of these results is that mutations in SEC9 affect a constitutive function, but that the temperature-sensitive phenotype is a manifestation of greater cellular requirement for this absent function under the increased physiological demands of higher temperature.
Plant invasion, which was not confirmed for E. tasmaniensis, may be an important requirement for the function (i.e. translocation of proteins into dedicated host cells).
Experiments in which Drosophila was used support an evolutionarily conserved requirement for the function of the S1P/S2P module during embryonic development.
The RI said it had taken the decision because its "requirement for the functions of the role of director as currently defined has ceased to exist".
To examine the structural requirements for the function of this unique cofactor, attempts were made to visualize solution structure of the PadA using small-angle X-ray scattering (SAXS) data and compare its shape profile with structural models based on crystal structures of staphylokinase and streptokinase domains.
In keeping with this requirement for CTGF function in fibrosis, FG-3019 also reduced the renal Hyp:Pro response up to 20% after UUO (P < 0.05).
Phosphorylation of a conserved aspartic acid residue in type-A ARRs is a critical requirement for their function in this negative feedback regulation (Lee et al. 2007).
Perhaps the increased nutritional demand of concurrent pregnancy and lactation is similarly altering placenta gene expression, and these changes could be increasing the requirement for Tex19.1 function in this tissue.
Nevertheless, the tripartite organisation of the lymphocytic immune system appears to be a fundamental requirement for efficient function, as this organisation is present both in jawed and jawless vertebrates, even though the manner of generating the defining receptors completely differs between these lineages.
In spite of this uncertainty, the requirement for mych function in zebrafish neural crest development supports the view that Myc family members are essential regulators of neural crest development in all vertebrates.
