Exact(1)
The 3+3 design is the most common method for dose evaluation in phase 1 studies and has the advantages of ease of implementation and interpretation, together with the requirement for smaller numbers of patients (Le Tourneau et al, 2009; Liu et al, 2013).
Similar(59)
One important feature of spectroelectrochemical methods is the requirement for small reagent volumes to minimize the time required for the cell and to reach equilibrium at a given applied potential.
Here the problem is the transparency requirement for small companies.
Since there is no longer a requirement for small companies to submit their accounts to independent audit, the difference in accounting costs will generally not be substantial.
But the critical requirement for small blocking-peptides is demonstrated in crystallographic structures of the complexes formed with selected tri- and tetrapeptides.
By relaxing the requirement for small variation of the transient, averaged parameters in the proposed solution formulation, the resulting analytical predictions are in excellent agreement with exact trajectories of displacement and velocity determined via numerical integration of the governing equation.
I'm personally just hoping that I'm ahead of the curve in my strict requirement for "small and silent".
The validation of biological quality control procedures for RCPs is a mandatory requirement for small scale radiopharmaceutical preparations (SSRP) in order to maintain good radiopharmacy practice (GRPP).
According to the LaMer model [18], separation of nucleation and crystal growth stages is the main requirement for small particle formation with narrow size distributions.
During the media portion of the forum, she said, "In reality, the bill can't be repealed". She went on to explain smaller steps can be taken including removing a tax provision requirement for small businesses, among other provisions that makes it difficult for businesses to thrive.
Unlike stochastic simulation methods, this has no requirement for small numbers of molecules and thus can be applied to cases where stochastic simulation is prohibitive.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com