Sentence examples for requirement for repressive from inspiring English sources

This late non-localized activity of Module C can now be attributed to SpRunt-1, which explains the late spatial requirement for repressive intermodular interactions in the context of the wnt8 cis-regulatory system [48].

HOTAIR interacts with Polycomb repressive complex 2 (PRC2) and is required for repressive histone H3 lysine-27 trimethylation (H3K27me3) of the HOXD cluster.

Consistent with the requirement for removal of both repressive H3K9 and H3K27 methylation marks, we show that dual inhibition of EHMT2 and EZH2 pharmacologically or by SiRNA is necessary for reactivation of certain genes and induces greater inhibition of cell growth than targeting either HKMT alone in triple negative breast cancer MDA-MB-231 cells.

Although several lines of evidence have supported the transrepression model, the requirement for receptor SUMOylation in the repressive actions of LXRs on inflammatory genes in cells and animals remains to be tested.

The exclusion of starvation-repressed genes from regions of repressive chromatin may reflect a requirement for the expression of these genes in cycling cells.

But they are often used in dubious ways and for repressive purposes.

TE-derived promoters are significantly enriched for active histone modifications, and depleted for repressive modifications, relative to the genomic background.

Conversely, macroH2A-containing mononucleosomes were enriched for repressive histone PTMs.

Therefore, similar to genes repressed by starvation, clustering of genes essential for growth likely reflects at least in part their exclusion from regions of repressive chromatin due to a requirement for their expression in cycling cells.

Several in vitro differentiation studies have revealed an acute requirement for the KDM6 H3K27me2/3 demethylases, KDM6A/UTX and KDM6B/JMJD3, in overcoming this repressive chromatin state to achieve normal gene expression during lineage commitment [ 87, 89– 94].

Similar to genes repressed by stress and/or essential for growth, a requirement for the expression of these genes may have lead to their evolutionary exclusion from regions of repressive chromatin.