In the particular case of CaMKII, multiple CaMs are required for the enzyme to reach an autophosphorylated state, placing a requirement for multiple CaMs bound to a single holoenzyme (42).
However, the requirement for multiple segmentations makes clinical trials laborious and time-consuming.
Some federal managers are keeping meetings small so they don't trigger the requirement for multiple approvals, although that means fewer employees are benefiting.
Actin remodeling at the lytic immunological synapse is a critical requirement for multiple facets of cytotoxic function.
The early clearance from plasma (short half-life) and requirement for multiple administrations and hence frequent physician visits make the overall treatment cost quite high.
The use of this multiepitope protein eliminates the requirement for multiple diagnostic intermediates for the development of anti-HCV diagnostic kit.
Conventional wire and rod forming processes have a number of drawbacks which include die wear, lubrication requirements, pre-cleaning of precursor stock and a requirement for multiple passes through dies to achieve significant reductions in diameter.
While small molecule labeling kits are available with a range of detection moieties, the workflow is hampered by a requirement for multiple dialysis-based buffer exchange steps that are both time-consuming and subject to sample loss.
The in vivo safety and efficacy of this gene-activated scaffold platform was demonstrated resulting in the successful transfection of host cells, abrogating the requirement for multiple procedures to isolate cells or ex vivo cell culture.
Furthermore, in contrast to the first minimal control model, there is no requirement for multiple ancilla qubits to implement the entangling gates.
The first is to find all itemsets that satisfy the minimum support; this step is generally expensive, due to the requirement for multiple passes over the database (see Fig. 1).
