Such a letter is a requirement for modification applications under the government's Making Home Affordable program.
There is no requirement for modification of the internal protein sequence by removing, for example, undesired cysteines.
Nor is there any requirement for modification of the protein at the chemical level by misincorporation of unnatural amino acids or by further modification of the expressed protein.
The above data suggest that if N-terminal residues are physiologically important and potential targets for low-level Rfa2 phosphorylation, there might be a requirement for modification of multiple residues (i.e., a critical mass of phosphorylation) to affect RFA's role in the DNA-damage response.
Within this study, the effects of design parameters on static and dynamic performance of spindle-bearing systems are analyzed in order to establish the requirement for design modifications, and the paper proposes a number of examples, along with a set of guidelines for the design of machine tool spindles.
However, having such a requirement for different modifications of a single inositide lipid allows for rapid control of signalling and maturation of the tubulation process.
ITC is the straightest path to complete the thermodynamic characterization of protein interaction without the requirement for chemical modification or labeling [157].
Recent research efforts have focused on incorporation of these catalysts into solid, electroactive supports, which can be challenging due to the requirement for synthetic modification to bpy ligands.
The drug interactions were classified into three groups, minor (55.29%), moderate (23.08%) and major (21.63%) according to the severity of and requirement for drug modification.
From this point of view, Lim et al. reported MAS5 superiority and the requirement for GCRMA modification when using human GeneChip data.
